3-羟基-4-甲基-2-亚甲基戊酸乙酯合成路线 （共 3 条）
反应条件
1,4-diaza-bicyclo[2.2.2]octane in ethanol; water; PEG 400 Baylis-Hillman Reaction; 456 h;
参考文献
Sanofi-Aventis
Patent: EP2298782 A1, 2011 ;
Location in patent: Page/Page column 25 ;
反应条件
1: propynoic acid ethyl ester With N-methyl-2-indolinone; diisobutylaluminium hydride in tetrahydrofuran; hexane T=0 - 20°C; Addition; 2: isobutyraldehyde in tetrahydrofuran; hexane T=20°C; Addition; 4 h;
参考文献
Ramachandran, P. Veeraraghavan; Rudd, Michael T.; Burghardt, Thomas E.; Ram Reddy, M. Venkat
Journal of Organic Chemistry, 2003 , vol. 68, # 24 p. 9310 - 9316
反应条件
in diethyl ether T=20°C; 1 h;
参考文献
Adam, Waldemar; Albert, Rainer; Hasemann, Ludwig; Nava Salgado, Victor O.; Nestler, Bernd; et al.
Journal of Organic Chemistry, 1991 , vol. 56, # 20 p. 5782 - 5785
