4,6-二羟基-2-苯基嘧啶合成路线 （共 7 条）
反应条件
sodium methylate; sodium chloride in methanol T=55°C; 2 h;
参考文献
JANUS BIOTHERAPEUTICS, INC.; LIPFORD, Grayson, B.; ZEPP, Charles, M.
Patent: WO2012/167046 A1, 2012 ;
Location in patent: Page/Page column 134 ;
反应条件
1: With sodium methylate in methanol T=55°C; 2 h; 2: With acetic acid in methanol; water 0.5 h;
参考文献
JANUS BIOTHERAPEUTICS, INC.; LIPFORD, Grayson, B.; ZEPP, Charles, M.
Patent: WO2012/167053 A1, 2012 ;
Location in patent: Page/Page column 92 ;
反应条件
sodium ethanolate in ethanol 3 h; Heating;
参考文献
Biagi; Giorgi; Livi; Scartoni; Lucacchini
Farmaco, 1997 , vol. 52, # 1 p. 61 - 65
反应条件
in dimethyl sulfoxide
参考文献
US5216159 A1, ;
US 5216159 A
反应条件
in dimethyl sulfoxide
参考文献
US5597920 A1, ;
US 5597920 A
反应条件
in trichlorophosphate
参考文献
Castelhano, Arlindo; McKibben, Bryan; Steinig, Arno; Collington, Eric
Patent: US2003/162764 A1, 2003 ;
US 20030162764 A1
反应条件
1: 70 percent / 90percent HNO3 / 1 h / Ambient temperature
2: 75 percent / POCl3, diethylamine / 1 h / 80 °C
View Scheme
参考文献
JANUS BIOTHERAPEUTICS, INC.; LIPFORD, Grayson, B.; ZEPP, Charles, M.
Patent: WO2012/167053 A1, 2012 ;
