1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; sodium carbonate / 1,4-dioxane; water / 24 h / Reflux 2: ethylenediamine / 1,4-dioxane; propan-1-ol; water / 24 h / Reflux View Scheme

1: 94 percent / bromine, sodium acetate / acetic acid / Ambient temperature View Scheme

PinP(O)H; [Pd(dibenzylideneacetone)2] in tetrahydrofuran; 1,4-dioxane T=80°C; Kumada cross-coupling reaction; 22 h;