potassium carbonate in N,N-dimethyl-formamide T=80°C; 6 h;

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C 2: trichlorophosphate / 3.5 h / 0 - 80 °C 3: potassium hydroxide / methanol; water / 24.5 h / 0 - 20 °C 4: palladium 10 on activated carbon; hydrogen / methanol; ethyl acetate / 72 h / 20 °C View Scheme

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C 2: trichlorophosphate / 3.5 h / 0 - 80 °C View Scheme