叔丁基 4-(2-乙氧基-2-氧代亚乙基)哌啶-1-羧酸合成路线 （共 21 条）
反应条件
sodium hydride in tetrahydrofuran T=20°C; Horner-Emmons reaction; 1 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1498125 A1, 2005 ;
Location in patent: Page/Page column 84-85 ;
EP 1498125 A1
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With potassium tert-butylate in DMF (N,N-dimethyl-formamide) T=0°C; 0.5 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 1.5 h;
参考文献
EP1489078 A1, ;
Page 189 ;
EP 1489078 A1
反应条件
1: (MeO)2P(O)CH2CO2Et With sodium hydride in tetrahydrofuran T=0°C; 1.5 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate With sodium hydrogencarbonate in tetrahydrofuran; water T=20°C;
参考文献
US2003/229074 A1, ;
Page 20 ;
US 20030229074 A1
反应条件
potassium carbonate in water; N,N-dimethyl-formamide
反应条件
potassium tert-butylate in tetrahydrofuran T=60°C; 4 h; Inert atmosphere;
参考文献
Russian Journal of Organic Chemistry, , vol. 50, # 1 p. 54 - 58
Zh. Org. Khim., , vol. 50, # 1 p. 61 - 65,5
反应条件
ammonium chloride in tetrahydrofuran; water
参考文献
US6140333 A1, ;
US 6140333 A
反应条件
sodium chloride; sodium hydrogencarbonate; triethylamine in methanol; anhydrous dichloroethane
反应条件
1: 10.9 g / aq. NaOH / tetrahydrofuran / 12 h / 20 °C 2: 9.5 g / toluene / 12 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 34, # 5 p. 363 - 380
反应条件
1: 10.9 g / aq. NaOH / tetrahydrofuran / 12 h / 20 °C 2: 9.5 g / toluene / 12 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 34, # 5 p. 363 - 380
反应条件
in toluene Wittig reaction; 12 h; Heating;
参考文献
Peschke, Bernd; Ankersen, Michael; Sehested Hansen, Birgit; Kruse Hansen, Thomas; Langeland Johansen, Nils; Lau, Jesper; Madsen, Kjeld; Petersen, Hans; Thogersen, Henning; Watson, Brett
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 5 p. 363 - 380
