叔丁基 4-(2-乙氧基-2-氧代亚乙基)哌啶-1-羧酸合成路线 （共 21 条）
反应条件
1: H2 / Pd/C / methanol / 20 °C 2: LAH / tetrahydrofuran / 20 °C 3: NEt3 / tetrahydrofuran / 0 °C View Scheme
参考文献
GRUENENTHAL GmbH
Patent: US2012/71461 A1, 2012 ;
反应条件
1: H2 / Pd/C / methanol / 20 °C 2: LAH / tetrahydrofuran / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 13 p. 2167 - 2172
反应条件
1: palladium 10 on activated carbon; hydrogen / ethanol / 5 h / 20 °C 2: hydrogenchloride; isopropyl alcohol / 16 h / 0 - 20 °C View Scheme
参考文献
SUVEN LIFE SCIENCES LIMITED; Nirogi, Ramakrishna; Mohammed, Abdul Rasheed; Yarlagadda, Suresh; Ravella, Srinivasa Rao; Shinde, Anil Karbhari; Kamphampati, Ramasastri; Roayapalley, Praveen Kumar; Jayarajan, Pradeep; Bhyrapuneni, Gopinadh; Patnala, Sriramachandra Murthy; Ravula, Jyothsna; Jasti, Venkateswarlu
Patent: US2014/187581 A1, 2014 ;
反应条件
1: palladium on activated charcoal; hydrogen / ethanol / 5 h / 20 °C 2: diisobutylaluminium hydride / dichloromethane; hexane / 3 h / -78 °C 3: 4-(N,N-dimethylamino)benzoic acid; pyrrolidine / dichloromethane / |Reflux; |Inert atmosphere 4: sodium tetrahydroborate / methanol / 2 h / 0 °C View Scheme
参考文献
Zhao, Yi; Jiang, Xiaojian; Yeung, Ying-Yeung
Angewandte Chemie - International Edition, 2013 , vol. 52, # 33 p. 8597 - 8601
Angew. Chem., 2013 , vol. 125, # 33 p. 8759 - 8763,5
反应条件
1: 100 percent / H2 / 10 percent Pd-C / ethyl acetate / 3 h / 3750.3 Torr 2: 67 percent / DIBAL-H / hexane; toluene / 0.17 h / -78 °C View Scheme
参考文献
Zhao, Yi; Jiang, Xiaojian; Yeung, Ying-Yeung
Angewandte Chemie - International Edition, 2013 , vol. 52, # 33 p. 8597 - 8601
Angew. Chem., 2013 , vol. 125, # 33 p. 8759 - 8763,5
反应条件
hydrogen; 10 palladium on active carbon in ethyl acetate P=3750.3 Torr; 3 h;
参考文献
Sato, Tatsunori; Okamoto, Kazuya; Nakano, Yuko; Uenishi, Jun'ichi; Ikeda, Masazumi
Heterocycles, 2001 , vol. 54, # 2 p. 747 - 755
反应条件
ammonium formate; palladium monocarbide in water
参考文献
MERCK SHARP and DOHME LTD.
Patent: EP470668 A1, 1992 ;
反应条件
1: palladium 10 on activated carbon; hydrogen / ethanol 2: water; potassium hydroxide / ethanol / 20 °C View Scheme
参考文献
Wang, Xiao Jian; Xi, Mei Yang; Fu, Ji Hua; Zhang, Fu Rong; Cheng, Gui Fang; Yin, Da Li; You, Qi Dong
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 707 - 710
反应条件
1: H2 / Pd/C / methanol / 20 °C 2: LAH / tetrahydrofuran / 20 °C 3: NEt3 / tetrahydrofuran / 0 °C 4: NaN3 / dimethylformamide / 20 °C 5: H2 / Pd/C / methanol / 20 °C View Scheme
参考文献
Ogino, Yoshio; Ohtake, Norikazu; Kobayashi, Kensuke; Kimura, Toshifumi; Fujikawa, Toru; Hasegawa, Takuro; Noguchi, Kazuhito; Mase, Toshiaki
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 13 p. 2167 - 2172
反应条件
sodium hydroxide in methanol T=25°C; 0.5 h;
参考文献
Wang, Xiao Jian; Xi, Mei Yang; Fu, Ji Hua; Zhang, Fu Rong; Cheng, Gui Fang; Yin, Da Li; You, Qi Dong
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 707 - 710
