1-Boc-4-哌啶甲酸乙酯合成路线 （共 21 条）
反应条件
hydrogen; 10 palladium on active carbon in ethyl acetate P=3750.3 Torr; 3 h;
参考文献
Sato, Tatsunori; Okamoto, Kazuya; Nakano, Yuko; Uenishi, Jun'ichi; Ikeda, Masazumi
Heterocycles, 2001 , vol. 54, # 2 p. 747 - 755
反应条件
4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide T=25°C; 24 h;
参考文献
SCHERING CORPORATION
Patent: EP931078 B1, 2006 ;
Location in patent: Page/Page column 73-74 ;
反应条件
sodium hydrogencarbonate in tetrahydrofuran T=0 - 20°C; 20 h;
参考文献
EP1489078 A1, ;
Page 188 ;
EP 1489078 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
EP1553074 A1, ;
Page/Page column 52 ;
反应条件
NaH; palladium monocarbide in tetrahydrofuran; ethanol; water; ethyl acetate
反应条件
ammonium formate; palladium monocarbide in water
反应条件
1: NaH / tetrahydrofuran / 0 °C 2: H2 / Pd/C / methanol / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 13 p. 2167 - 2172
反应条件
1: With sodium hydride Horner-Wadsworth-Emmons Olefination; 2: With hydrogen; palladium 10 on activated carbon in ethanol
参考文献
US2004/2504 A1, ;
Page/Page column 30-31 ;
US 20040002504 A1
反应条件
1: sodium hydrogencarbonate / tetrahydrofuran / 6 h / 25 °C 2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 78 °C 3: palladium 10 on activated carbon; hydrogen / ethanol / 7 h / 25 °C View Scheme
参考文献
Chinese Chemical Letters, , vol. 23, # 6 p. 707 - 710
反应条件
1: sodium hydrogencarbonate / tetrahydrofuran / 6 h / 25 °C 2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 78 °C 3: palladium 10 on activated carbon; hydrogen / ethanol / 7 h / 25 °C View Scheme
参考文献
Chinese Chemical Letters, , vol. 23, # 6 p. 707 - 710
