1-Boc-4-哌啶甲酸乙酯合成路线 （共 21 条）
反应条件
sodium hydrogencarbonate in acetone 22 h; Reflux;
参考文献
WO2010/91382 A1, ;
Page/Page column 41 ;
WO 2010/091382 A1
反应条件
1: LAH / tetrahydrofuran / 20 °C 2: NEt3 / tetrahydrofuran / 0 °C View Scheme
参考文献
GRUENENTHAL GmbH
Patent: US2012/71461 A1, 2012 ;
反应条件
lithium borohydride in methanol; diethyl ether; water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5753664 A1, 1998 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 13 p. 2167 - 2172
参考文献
US6140333 A1, ;
US 6140333 A
反应条件
hydrogenchloride; isopropyl alcohol T=0 - 20°C; 16 h;
参考文献
SUVEN LIFE SCIENCES LIMITED; Nirogi, Ramakrishna; Mohammed, Abdul Rasheed; Yarlagadda, Suresh; Ravella, Srinivasa Rao; Shinde, Anil Karbhari; Kamphampati, Ramasastri; Roayapalley, Praveen Kumar; Jayarajan, Pradeep; Bhyrapuneni, Gopinadh; Patnala, Sriramachandra Murthy; Ravula, Jyothsna; Jasti, Venkateswarlu
Patent: US2014/187581 A1, 2014 ;
Location in patent: Paragraph 0162-0165 ;
反应条件
in 1,4-dioxane; ethanol
参考文献
Schering Corporation; Pharmacopeia Inc.
Patent: US5965570 A1, 1999 ;
反应条件
1: diisobutylaluminium hydride / dichloromethane; hexane / 3 h / -78 °C 2: 4-(N,N-dimethylamino)benzoic acid; pyrrolidine / dichloromethane / |Reflux; |Inert atmosphere 3: sodium tetrahydroborate / methanol / 2 h / 0 °C View Scheme
参考文献
Zhao, Yi; Jiang, Xiaojian; Yeung, Ying-Yeung
Angewandte Chemie - International Edition, 2013 , vol. 52, # 33 p. 8597 - 8601
Angew. Chem., 2013 , vol. 125, # 33 p. 8759 - 8763,5
反应条件
diisobutylaluminium hydride in hexane; toluene T=-78°C; 0.166667 h;
参考文献
Sato, Tatsunori; Okamoto, Kazuya; Nakano, Yuko; Uenishi, Jun'ichi; Ikeda, Masazumi
Heterocycles, 2001 , vol. 54, # 2 p. 747 - 755
反应条件
sodium hydroxide in methanol T=25°C; 0.5 h;
参考文献
Wang, Xiao Jian; Xi, Mei Yang; Fu, Ji Hua; Zhang, Fu Rong; Cheng, Gui Fang; Yin, Da Li; You, Qi Dong
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 707 - 710
