2,6-二氯咪唑并[2,1-b][1,3]噻唑合成路线 (共 2 条)
反应条件
N,N-diethylaniline; trichlorophosphate in toluene 3 h; Heating / reflux;
参考文献
UCB S.A.
Patent: WO2006/128692 A2, 2006 ;
Location in patent: Page/Page column 130; 131 ;
反应条件
trichlorophosphate 1.) EtOH, reflux, 6 h, 2.) reflux, 3 h; Yield given. Multistep reaction;
参考文献
Andreani; Rambaldi; Locatelli; Isetta
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 3 p. 335 - 337