(S)-N-(1-氮杂双环环[2.2.2]-3-辛基)-5,6,7,8-四氢-1-萘羧酰胺合成路线 (共 5 条)
反应条件
1: SOCl2, DMF / toluene / 2 h / 20 - 50 °C 2: ethyl acetate; toluene / 18 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 18 p. 2645 - 2657
反应条件
1: (S)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride With sodium hydroxide; water in toluene T=60°C; 1 h; 2: 5,6,7,8-tetrahydronaphthylene-1-carboxylic acid chloride in toluene T=60°C; 1.5 h; Product distribution / selectivity;
参考文献
Rossetto, Pierluigi; MacDonald, Peter; Bigatti, Ettore; Banfi, Gaia; Tentorio, Dario
Patent: US2008/200681 A1, 2008 ;
Location in patent: Page/Page column 11 ;
反应条件
in toluene T=40 - 65°C; Inert atmosphere;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; KATKAM, Srinivas; SAGYAM, Rajeshwar Reddy; SUNKARA, Vishnuvardhan; MUNAGALA, Sridhar; MUTTAVARAPU, Murali Mohan
Patent: WO2010/56656 A2, 2010 ;
Location in patent: Page/Page column 22 ;
反应条件
in N-methyl-acetamide; dichloromethane; water
反应条件
sodium hydroxide; n-butyllithium in tetrahydrofuran; N-methyl-acetamide; hexane
参考文献
Syntex (U.S.A.) Inc.
Patent: US5202333 A1, 1993 ;