N-叔丁氧羰基-L-谷氨酸5-苄酯合成路线 （共 35 条）
反应条件
pyridine in acetonitrile T=20°C; 1.5 h; further solvent, base;
参考文献
Il'ina, A. V.; Davidovich, Yu. A.; Rogozhin, S. V.; Moiseenkov, A. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, p. 1067 - 1070
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 5 p. 1163 - 1165
反应条件
1: potassium carbonate / dimethylformamide 2: 42 g / H2 / Pd/C / ethanol View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 5, # 12 p. 1915 - 1923
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
REMPEX PHARMACEUTICALS, INC.; GLINKA, Tomasz; HIGUCHI, Robert; HECKER, Scott; EASTMAN, Brian; RODNY, Olga
Patent: WO2012/109164 A1, 2012 ;
Location in patent: Page/Page column 39 ;
WO 2012/109164 A1
反应条件
1: 4(S)-carboxy-4-(N-t-butoxycarbonylamino)butanoic acid benzyl ester With potassium carbonate in acetone 0.166667 h; Inert atmosphere; 2: dimethyl sulfate in acetone T=20°C; 1 h; Inert atmosphere;
参考文献
Chakraborty, Subrata; Tai, Dar-Fu
Tetrahedron Letters, 2014 , vol. 55, # 14 p. 2274 - 2276
反应条件
triethylamine; isobutyl chloroformate
参考文献
Nouvet, Andre; Lamaty, Frederic; Lazaro, Rene
Tetrahedron Letters, 1998 , vol. 39, # 15 p. 2099 - 2102
反应条件
in diethyl ether; ethanol T=65°C; 0.333333 h;
参考文献
Boudreault, Pierre-Luc; Voyer, Normand
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 9 p. 1459 - 1465
反应条件
1: DCC / CH2Cl2 / 0.5 h / 0 °C 2: 2.1 g / CH2Cl2 / 16 h View Scheme
参考文献
Biron, Eric; Voyer, Normand
Chemical Communications, 2005 , # 37 p. 4652 - 4654
反应条件
in methanol; benzene
参考文献
Hamada; Shioiri
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 5 p. 1921 - 1924
反应条件
1: ClCO2Et 2: AgO2CCF3 View Scheme
参考文献
Organic Letters, , vol. 2, # 13 p. 1943 - 1946
反应条件
1: 1.) CDI / 1.) THF, 0 deg C to room temperature, 2.) 0 deg C to room temperature
2: H2 / Pd/C / tetrahydrofuran
3: 78 percent / EDC, DMAP / acetonitrile / Ambient temperature
4: 75 percent / Et3SiH / Pd/C / acetone / 2 h / Ambient temperature
View Scheme
参考文献
Tamura, Susan Y.; Goldman, Erick A.; Brunck, Terence K.; Ripka, William C.; Semple, J. Edward
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 3 p. 331 - 336
