N-叔丁氧羰基-L-谷氨酸5-苄酯合成路线 （共 35 条）
反应条件
1: 92.2 percent / N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH2Cl2 / 22 h / 0 - 20 °C
2: 4 N HCl / dioxane / 1 h / Ambient temperature
3: N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH2Cl2 / 22 h / 0 - 20 °C
4: 90 percent / H2 / 10percent Pd/C / 2-methyl-propan-2-ol / 7 h
View Scheme
参考文献
Rich, Daniel H.; Lehrman, S. Russ; Kawai, Megumi
Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 706 - 711
反应条件
Yield given. Multistep reaction;
参考文献
St-Pierre, S.; Lalonde, J.-M.; Gendreau, M.; Quirion, R.; Regoli, D.; Rioux, F.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 4 p. 370 - 376
反应条件
1: NaHCO3 / dimethylformamide / 20 °C
2: H2; Pd/C / dioxane / 20 °C
View Scheme
参考文献
Ajinomoto Co., Inc.; YASUDA, Reiko; ETO, Yuzuru
Patent: EP2554165 A1, 2013 ;
反应条件
1.1: LiHMDS / tetrahydrofuran / 0.5 h / -78 °C
1.2: 83 percent / tetrahydrofuran / 1 h / -78 °C
2.1: 100 percent / H2 / Pd/C / methanol / 12 h / 20 °C
3.1: 80 percent / DCC / CH2Cl2 / 12 h / -20 °C
4.1: 34 percent / 132 h / -196 °C
View Scheme
参考文献
Spantulescu, M. Daniel; Jain, Rajendra P.; Derksen, Darren J.; Vederas, John C.
Organic Letters, 2003 , vol. 5, # 16 p. 2963 - 2965
反应条件
1.1: 4-methyl-morpholine; TBTU / CH2Cl2 / 0 °C
2.1: TFA; anisole / CH2Cl2 / 20 °C
2.2: HCl / methanol
3.1: 4-methyl-morpholine; TBTU / CH2Cl2 / 0 °C
4.1: H2; AcOH / 10 percent Pd/C / methanol
View Scheme
参考文献
Rysz; Redlinski; Mudyna; Luciak; Kaminski
Acta Poloniae Pharmaceutica - Drug Research, 2000 , vol. 57, # SUPPL. p. 11 - 14
