1: ammonia / water / 1 h / 65 °C 2: phosphorus oxytribromide / 1,2-dichloro-ethane / 1 h / 85 °C 3: palladium diacetate; [(t-Bu)3PH]BF4; caesium carbonate / N,N-dimethyl-formamide / 2 h / 120 °C 4: hydrogenchloride; water / ethanol / 1 h / 85 °C 5: dichloromethane / 15 h / |Reflux 6: triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C View Scheme

ammonia in water T=65°C; 1 h;

1: ammonia / water / 1 h / 65 °C 2: phosphorus oxytribromide / 1,2-dichloro-ethane / 1 h / 85 °C View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 &deg;C / |Inert atmosphere<br />1.2: 2 h / -78 - 20 &deg;C / |Inert atmosphere<br />2.1: trifluoroacetic acid / toluene / 16 h / 25 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: oxalyl dichloride / chloroform / 4 h / |Reflux<br />2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 &deg;C<br />2.2: 2.5 h / -78 - 20 &deg;C<br />2.3: -10 - 20 &deg;C<br /> <br /> &nbsp;