4-(3,4-二甲氧苯基)丁酸合成路线 （共 32 条）
反应条件
triethylsilane; trifluoroacetic acid 2 h; Reflux;
参考文献
European Journal of Medicinal Chemistry, , vol. 53, p. 52 - 63
反应条件
hydrogen; palladium on activated charcoal
参考文献
Journal of Organic Chemistry, , vol. 50, # 24 p. 4933 - 4938
反应条件
1,10-phenanthroline; potassium tert-butylate; anhydrous copper acetate in toluene T=-78 - 100°C; P=760.051 Torr;
参考文献
Organic Letters, , vol. 13, # 5 p. 1086 - 1088
反应条件
1: 95 percent / NaH / tetrahydrofuran; dimethylsulfoxide / 20 h / Ambient temperature 2: 95 percent / H2 / Pd/C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 50, # 24 p. 4933 - 4938
反应条件
1: H2 / Pd-C / acetic acid 2: LiAlH4 / diethyl ether 3: PBr3 / benzene 4: (i) Mg, Et2O, THF, (ii) /BRN= 1900390/ View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 9, p. 27 - 29
反应条件
1: AlCl3 / nitrobenzene / Ambient temperature 2: H2 / Pd/C / acetic acid / 65 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 13 p. 1747 - 1752
反应条件
1: PBr3 / benzene 2: (i) Mg, Et2O, THF, (ii) /BRN= 1900390/ View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 9, p. 27 - 29
反应条件
1: LiAlH4 / diethyl ether 2: PBr3 / benzene 3: (i) Mg, Et2O, THF, (ii) /BRN= 1900390/ View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 9, p. 27 - 29
反应条件
1: toluene / 1 h / 60 °C / Inert atmosphere; Sealed tube 2: 1,10-phenanthroline; potassium tert-butylate; anhydrous copper acetate / toluene / -78 - 100 °C / 760.05 Torr View Scheme
参考文献
Organic Letters, , vol. 13, # 5 p. 1086 - 1088
反应条件
1: With palladium on activated charcoal in methanol T=20°C; 0.166667 h; Inert atmosphere; 2: With hydrogen in methanol 4 h; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 78, # 16 p. 7823 - 7844
