4-(3,4-二甲氧苯基)丁酸合成路线 （共 32 条）
反应条件
titanium tetrachloride; propyl bromide 1.) Et2O, THF, a.) RT, 3h, b.) reflux 9h; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 44, # 3 p. 500 - 508
反应条件
(i) Mg, Et2O, THF, (ii) /BRN= 1900390/; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 9, p. 27 - 29
反应条件
1: polyphosphoric ester 2: potassium hydroxide / ethanol; water / 20 °C 3: palladium 10 on activated carbon; hydrogen / ethyl acetate / 1 h / 20 °C / 1551.49 Torr / Autoclave View Scheme
参考文献
Deck, Lorraine M.; Mgani, Quintino; Martinez, Andrea; Martinic, Alice; Whalen, Lisa J.; Vander Jagt, David L.; Royer, Robert E.
Tetrahedron Letters, 2012 , vol. 53, # 4 p. 373 - 376
反应条件
trichloro acetic anhydride T=70°C; Friedel Crafts acylation; 0.1 h; Neat (no solvent);
参考文献
Synthetic Communications, , vol. 39, # 15 p. 2664 - 2673
反应条件
1: concentrated sulfuric acid 2: concentrated aqueous HCl; amalgamated zinc / Erhitzen des Reaktionsprodukts mit Selen auf 270-290grad View Scheme
参考文献
Haworth; Mavin
Journal of the Chemical Society, 1932 , p. 1485,1486
反应条件
1: 93 percent / polyphosphoric acid / 4 h / 40 °C 2: 3 percent / HBr View Scheme
参考文献
Beugelmans, Rene; Chastanet, Jacqueline; Ginsburg, Helene; Quintero-Cortes, Leticia; Roussi, Georges
Journal of Organic Chemistry, 1985 , vol. 50, # 24 p. 4933 - 4938
反应条件
1: 93 percent / polyphosphoric acid / 4 h / 40 °C 2: 40 percent / HBr View Scheme
参考文献
Beugelmans, Rene; Chastanet, Jacqueline; Ginsburg, Helene; Quintero-Cortes, Leticia; Roussi, Georges
Journal of Organic Chemistry, 1985 , vol. 50, # 24 p. 4933 - 4938
反应条件
1: polyphosphoric acid 2: O2, KOtBu / 2-methyl-propan-2-ol View Scheme
参考文献
Buckle; Cantello; Smith; Spicer
Journal of Medicinal Chemistry, 1977 , vol. 20, # 8 p. 1059 - 1064
反应条件
1: polyphosphoric acid 2: nBuONO, KOtBu / butan-1-ol; diethyl ether 3: Zn / acetic acid 4: NaBH4 5: aq. NaOH / methanol 6: aq. HCl / benzene View Scheme
参考文献
Thrift,R.I.
Journal of the Chemical Society [Section] C: Organic, 1967 , p. 288 - 293
反应条件
1: PCl5; benzene
2: benzene; diethyl ether / Erhitzen des Reaktionsprodukts
3: peroxybenzoic acid
4: benzene; sodium methylate; methanol
View Scheme
参考文献
Howell; Taylor
Journal of the Chemical Society, 1958 , p. 1248,1251
