1.1: water; lithium hydroxide hydrate / tetrahydrofuran; methanol / 3 h / 18 - 25 °C 1.2: 0 °C 2.1: N-ethyl-N,N-diisopropylamine; HATU / isobutyramide / 1 h / 18 - 25 °C View Scheme

1.1: water; lithium hydroxide hydrate / tetrahydrofuran; methanol / 3 h / 18 - 25 °C 1.2: 0 °C 2.1: N-ethyl-N,N-diisopropylamine; HATU / isobutyramide / 1 h / 18 - 25 °C 3.1: borane-THF / tetrahydrofuran / 18 - 25 °C 3.2: 3 h 3.3: pH ~ 10 View Scheme