triethylamine in dichloromethane T=20°C; 2 h;

in toluene T=-10°C;

ClPhOPOCl2 in pyridine 72 h; Ambient temperatureother reagents, solvent;

in dichloromethane 1 h; Ambient temperature;

1: 1.) BSA / 1.) MeCN, 2.) MeCN, 80 deg C, 20 h 2: 70 percent / ClPhOPOCl2 / pyridine / 72 h / Ambient temperature; other reagents, solvent View Scheme

N-ethyl-N,N-diisopropylamine T=90°C; 2 h; Inert atmosphereNeat (no solvent);

1: 2-[3-(cyano-dimethyl-methyl)-5-hydroxymethyl-phenyl]-2-methyl-propionitrile With sodium hydride in tetrahydrofuran T=70°C; 0.5 h; 2: 1-(4-toluenesulfonyl)-1H-1,2,4-triazole in isobutyramide T=20°C; 0.333333 h; Product distribution / selectivity;