potassium hydroxide in methanol; water T=80°C; 3 h;

sodium chloride in methanol; hexane; dichloromethane; water; dimethyl sulfoxide

1: 80 percent / triethylamine / Ambient temperature 2: 93 percent / triethylamine / 60 °C 3: 85 percent / KOH / methanol; H2O / 3 h / 80 °C View Scheme

1: 0.86 percent / NaHCO3 / CHCl3; H2O / 2 h / Ambient temperature 2: 93 percent / H2 / 5percent Pd/C / methanol 3: 15.5 percent / dimethylformamide / 1.5 h / 50 °C 4: 317 mg / H2O; ethanol / 72 h / 50 °C 5: 61 percent / DBU / tetrahydrofuran / 2 h / 60 °C 6: 72 percent / H2 / 10percent Pd/C / ethanol 7: 58 percent / TFA / 2 h / Ambient temperature View Scheme