(S)-3-氧代-1-苯基丙基氨基甲酸叔丁酯合成路线 （共 20 条）
反应条件
1: acetaldehyde With (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine in chloroform T=20°C; 0.0833333 h; 2: N-[phenyl(toluene-4-sulfonyl)methyl]tert-butoxycarboxyamide With potassium fluoride in chloroform T=20°C; Mannich reaction; 24 h; optical yield given as percent eeenantioselective reaction;
参考文献
Chemistry - A European Journal, , vol. 16, # 20 p. 6069 - 6076
反应条件
1: 90 percent / aq. NaHCO3 2: 75 percent / diisobutylaluminium hydride / CH2Cl2 / -78 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 30 p. 5005 - 5007
反应条件
1: 90 percent / aq. NaHCO3 2: 75 percent / diisobutylaluminium hydride / CH2Cl2 / -78 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 30 p. 5005 - 5007
反应条件
1: tetrahydrofuran / Ambient temperature 2: TEA / CH2Cl2 / Ambient temperature 3: dimethylsulfoxide / 45 °C 4: 69 percent / DIBAL-H / toluene; diethyl ether / -40 °C View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. 134, # 7 p. 713 - 718
反应条件
1: dimethylsulfoxide / 45 °C 2: 69 percent / DIBAL-H / toluene; diethyl ether / -40 °C View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. 134, # 7 p. 713 - 718
反应条件
1: TEA / CH2Cl2 / Ambient temperature 2: dimethylsulfoxide / 45 °C 3: 69 percent / DIBAL-H / toluene; diethyl ether / -40 °C View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. 134, # 7 p. 713 - 718
反应条件
sodium tris(acetoxy)borohydride; acetic acid in 1,2-dichloro-ethane T=0 - 20°C; 3 h; Inert atmosphere;
参考文献
Asano, Shigehiro; Gavrilyuk, Julia; Burton, Dennis R.; Barbas, Carlos F.
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 2 p. 133 - 137
反应条件
sodium tris(acetoxy)borohydride in dichloromethane
参考文献
Price, David A.; Gayton, Simon; Selby, Matthew D.; Ahman, Jens; Haycock-Lewandowski, Sarah; Stammen, Blanda L.; Warren, Andrew
Tetrahedron Letters, 2005 , vol. 46, # 30 p. 5005 - 5007
反应条件
sodium tetrahydroborate in methanol T=-78 - 20°C; 12 h;
参考文献
Journal of the American Chemical Society, , vol. 129, # 34 p. 10336 - 10337
反应条件
1: 75 percent / Na(AcO)3BH / CH2Cl2 2: 95 percent / CF3CO2H / CH2Cl2 3: 49 percent / polimer bound carbodiimide / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Price, David A.; Gayton, Simon; Selby, Matthew D.; Ahman, Jens; Haycock-Lewandowski, Sarah; Stammen, Blanda L.; Warren, Andrew
Tetrahedron Letters, 2005 , vol. 46, # 30 p. 5005 - 5007
