L-脯氨酰-L-苯丙氨酸合成路线 （共 11 条）
反应条件
hydrogen bromide in acetic acid RT, 1 h;then 60 deg C., 0.5 h;
参考文献
Freund, Matthias H.; Tsogoeva, Svetlana B.
Synlett, 2011 , # 4 p. 503 - 507
反应条件
trifluoroacetic acid in dichloromethane T=22°C;
参考文献
Gautschi, Markus; Schmid, Joachim P.; Peppard, Terry L.; Ryan, Thomas P.; Tuorto, Raymond M.; Yang, Xiaogen
Journal of Agricultural and Food Chemistry, 1997 , vol. 45, # 8 p. 3183 - 3189
反应条件
1: 1.) N-methylmorpholine, ClCO2iBu, 2.) N-methylmorpholine / 1.) THF, -15 deg C, 2 min, 2.) THF, DMF, -15 deg C, 1 h 2: TFA / CH2Cl2 / 22 °C View Scheme
参考文献
Freund, Matthias H.; Tsogoeva, Svetlana B.
Synlett, 2011 , # 4 p. 503 - 507
反应条件
1: 1.) N-methylmorpholine, ClCO2iBu, 2.) N-methylmorpholine / 1.) THF, -15 deg C, 2 min, 2.) THF, DMF, -15 deg C, 1 h 2: TFA / CH2Cl2 / 22 °C View Scheme
参考文献
Gautschi, Markus; Schmid, Joachim P.; Peppard, Terry L.; Ryan, Thomas P.; Tuorto, Raymond M.; Yang, Xiaogen
Journal of Agricultural and Food Chemistry, 1997 , vol. 45, # 8 p. 3183 - 3189
反应条件
sulfuric acid; water T=80 - 85°C; 2 h; Yield given;
参考文献
Sawayama; Itokawa; Shimada; Doi; Kimura; Nishim ura
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 2 p. 529 - 531
反应条件
1: 40.6 g / DCC, NEt3 / CH2Cl2 / Ambient temperature 2: H2SO4, H2O / 2 h / 80 - 85 °C View Scheme
参考文献
Sawayama; Itokawa; Shimada; Doi; Kimura; Nishim ura
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 2 p. 529 - 531
反应条件
1: 95.1 percent / NaOMe / methanol; 1,2-dichloro-ethane / 1 h / Ambient temperature 2: 40.6 g / DCC, NEt3 / CH2Cl2 / Ambient temperature 3: H2SO4, H2O / 2 h / 80 - 85 °C View Scheme
参考文献
Sawayama; Itokawa; Shimada; Doi; Kimura; Nishim ura
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 2 p. 529 - 531
反应条件
1: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 1 h / 20 °C 2: palladium on carbon; hydrogen / methanol / 15 h / 20 °C / 760.05 Torr View Scheme
参考文献
Freund, Matthias H.; Tsogoeva, Svetlana B.
Synlett, 2011 , # 4 p. 503 - 507
反应条件
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 °C 1.2: 17 h / 20 °C 2.1: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 1 h / 20 °C 3.1: palladium on carbon; hydrogen / methanol / 15 h / 20 °C / 760.05 Torr View Scheme
参考文献
Freund, Matthias H.; Tsogoeva, Svetlana B.
Synlett, 2011 , # 4 p. 503 - 507
参考文献
Dainippon Pharmaceutical Co., Ltd.
Patent: US4248883 A1, 1981 ;
