1: (1-{(R)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)vinyl]phenyl}-3-[2-(1-methyl-1-trimethylsilanyloxyethyl)phenyl]propylsulfanylmethyl}cyclopropyl)acetic acid methyl ester With water; sodium hydroxide in 2-methyl tetrahydrofuran; methanol T=70 - 80°C; 2 h; Inert atmosphere; 2: N,N-dicyclohexylamine in hexane; ethyl acetate T=20°C;

1.1: sodium hydroxide; water / 2-methyl tetrahydrofuran; methanol / 2 h / 70 - 80 °C / Inert atmosphere 1.2: 20 °C 2.1: potassium dihydrogenphosphate / dichloromethane; water / 0.25 h / 20 °C 2.2: 0.25 h View Scheme