3,4'-二己基-2,2'-并噻吩合成路线 （共 30 条）
反应条件
trimethylsilyl bromide; hexafluoroisopropyl alcohol; (hydroxy(tosyloxy)iodo)benzene T=20°C; 3 h; regioselective reaction;
参考文献
Dohi, Toshifumi; Yamaoka, Nobutaka; Nakamura, Shota; Sumida, Kohei; Morimoto, Koji; Kita, Yasuyuki
Chemistry - A European Journal, 2013 , vol. 19, # 6 p. 2067 - 2075
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 1 h;
参考文献
Turner, David J.; Anemian, Remi; MacKie, Philip R.; Cupertino, Domenico C.; Yeates, Stephen G.; Turner, Michael L.; Spivey, Alan C.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 11 p. 1752 - 1763
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in water; toluene T=90°C; Suzuki coupling; 6 h; Inert atmosphere; regioselective reaction;
参考文献
El-Shehawy, Ashraf A.; Abdo, Nabiha I.; El-Barbary, Ahmed A.; Lee, Jae-Suk
Tetrahedron Letters, 2010 , vol. 51, # 34 p. 4526 - 4529
反应条件
1: 2-bromo-4-n-hexylthiophen With iodine; magnesium in diethyl ether T=0°C; 4.5 h; RefluxInert atmosphere; 2: 2-bromo-3-(n-hexyl)thiophene With [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in diethyl ether Kumada coupling reaction; 12.5 h; RefluxCooling with iceInert atmosphere; regioselective reaction;
参考文献
El-Shehawy, Ashraf A.; Abdo, Nabiha I.; El-Barbary, Ahmed A.; Lee, Jae-Suk
Tetrahedron Letters, 2010 , vol. 51, # 34 p. 4526 - 4529
反应条件
1: 3-Hexylthiophene With (2,2,6,6-tetramethylpiperidinyl)MgCl*LiCl in tetrahydrofuran T=20°C; 3 h; Inert atmosphere; 2: 2-bromo-3-(n-hexyl)thiophene With bis(1,5-cyclooctadiene)nickel (0); SlPr in tetrahydrofuran T=60°C; 20 h; Inert atmosphere; regioselective reaction;
参考文献
Tanaka, Shota; Tanaka, Daiki; Tatsuta, Go; Murakami, Kohei; Tamba, Shunsuke; Sugie, Atsushi; Mori, Atsunori
Chemistry - A European Journal, 2013 , vol. 19, # 5 p. 1658 - 1665
反应条件
1: 3-Hexylthiophene With 2,2,6,6-tetramethyl-piperidine; ethyl magnesium chloride in tetrahydrofuran 24 h; Inert atmosphereReflux; 2: 2-chloro-3-(n-hexyl)-thiophene With [NiCl2(N,N'-bis[(2,6-diisopropylphenyl)imidazol]-2-ylidene)(PPh3)] in tetrahydrofuran T=60°C; 21 h; Inert atmosphere;
参考文献
Tanaka, Shota; Tanaka, Daiki; Tatsuta, Go; Murakami, Kohei; Tamba, Shunsuke; Sugie, Atsushi; Mori, Atsunori
Chemistry - A European Journal, 2013 , vol. 19, # 5 p. 1658 - 1665
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-80 - 20°C; Metallation; 2: With iron (III) acetylacetonate in tetrahydrofuran; hexane T=20°C; Oxidation; 2.2 h;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 71, # 2 p. 483 - 495
反应条件
water; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether Dimerization; Cross-coupling; 3 h; Heating;
参考文献
Kirschbaum, Thomas; Briehn, Christoph A.; Baeuerle, Peter
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 8 p. 1211 - 1216
反应条件
tetrakis(triphenylphosphine) palladium(0); Aliquatreg; 336; sodium carbonate in tetrahydrofuran; toluene T=80°C; 24 h;
参考文献
Kim, Ji-Hoon; Lee, Sunyoung; Kang, In-Nam; Park, Moo-Jin; Hwang, Do-Hoon
Journal of Polymer Science, Part A: Polymer Chemistry, 2012 , vol. 50, # 16 p. 3415 - 3424
反应条件
cesium fluoride; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran 8 h; Heating;
参考文献
Klok, Harm-Anton; Roesler, Annette; Goetz, Guenther; Mena-Osteritz, Elena; Baeuerle, Peter
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 24 p. 3541 - 3544
