3-苯基-1H-吡唑-5-羧酸乙酯合成路线 （共 8 条）
反应条件
1: With potassium tert-butylate in tetrahydrofuran T=0 - 30°C; 15 h; 2: With acetic acid; hydrazine in tetrahydrofuran 2 h; Heating / reflux;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2007/18314 A2, 2007 ;
Location in patent: Page/Page column 115 ;
WO 2007/018314 A2
反应条件
sodium carbonate in methanol T=65°C; 2 h; SolventReagent/catalystTemperature; regioselective reaction;
参考文献
Shao, Nana; Chen, Tong; Zhang, Taotao; Zhu, Huajian; Zheng, Qunxiong; Zou, Hongbin
Tetrahedron, 2014 , vol. 70, # 4 p. 795 - 799
反应条件
Montmorillonite K10; hydrazine hydrate in isopropyl alcohol Heating;
参考文献
Jagath Reddy; Latha; Srinivasa Rao
Organic Preparations and Procedures International, 2004 , vol. 36, # 5 p. 494 - 498
反应条件
T=120°C; 0.166667 h; microwave irradiation;
参考文献
Zrinski, Irena; Juribasic, Marina; Eckert-Maksic, Mirjana
Heterocycles, 2006 , vol. 68, # 9 p. 1961 - 1967
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=20°C; Inert atmosphere; regioselective reaction;
参考文献
Tetrahedron Letters, , vol. 50, # 44 p. 5978 - 5980
反应条件
hydrazine monohydrochloride 4 h; Heating;
参考文献
Martins; Freitag; Flores; Zanatta
Synthesis, 1995 , # 12 p. 1491 - 1492
反应条件
1: NaOC2H5 2: N2H4; acetic acid / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 24 p. 6342 - 6347
反应条件
Alkaline hydrolysis;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 17 p. 4914 - 4919
