3-氰基-4-三氟甲基吡啶合成路线 （共 7 条）
反应条件
sodium methylate in methanol T=20°C; 2 h; Heating / reflux;
参考文献
Sankyo Agro Company, Limited
Patent: EP1460071 A1, 2004 ;
Location in patent: Page 39 ;
反应条件
sodium methylate in methanol T=20°C; 2 h; Heating / reflux;
参考文献
Sankyo Agro Company, Limited
Patent: EP1460071 A1, 2004 ;
Location in patent: Page 39 ;
反应条件
sodium methylate in methanol T=20°C; 2 h; Heating / reflux;
参考文献
Sankyo Agro Company, Limited
Patent: EP1460071 A1, 2004 ;
Location in patent: Page 39 ;
反应条件
in N,N-dimethyl-formamide T=80°C; 8 h; Sealed tubeInert atmosphere;
参考文献
Mormino, Michael G.; Fier, Patrick S.; Hartwig, John F.
Organic Letters, 2014 , vol. 16, # 6 p. 1744 - 1747
反应条件
dihydrogen peroxide; trifluoroacetic anhydride in dichloromethane; water T=0 - 40°C;
参考文献
ASTRAZENECA AB
Patent: WO2006/68618 A1, 2006 ;
Location in patent: Page/Page column 36 ;
WO 2006/068618 A1
反应条件
ammonia; hydrogen; nickel in ethanol P=25858.1 Torr; 1 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/66126 A1, 2005 ;
Location in patent: Page/Page column 60 ;
WO 2005/066126 A1
反应条件
1: With potassium hydroxide; water in water; ethylene glycol T=200°C; 4 h; 2: With hydrogenchloride in water; ethylene glycol T=20°C;
参考文献
Sankyo Agro Company, Limited
Patent: EP1460071 A1, 2004 ;
Location in patent: Page 40; 41 ;
