1.1: sodium hypochlorite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; tetraethylammonium bromide; sodium hydrogencarbonate / dichloromethane / 2 - 5 °C / Inert atmosphere 1.2: Inert atmosphere 2.1: dichloromethane / 20 °C / Inert atmosphere; Large scale reaction 3.1: dichloromethane / -15 - 0 °C / Inert atmosphere 4.1: sodium hydroxide / methanol; water / 5 - 40 °C / Inert atmosphere; Large scale reaction 4.2: pH 1 - 2 / Inert atmosphere; Large scale reaction 5.1: dichloromethane / 2 h / 20 °C / Inert atmosphere; Large scale reaction 6.1: triethylamine / dichloromethane / -10 °C / Inert atmosphere; Large scale reaction 7.1: methanesulfonic acid; water / 10 h / 70 °C / Inert atmosphere; Large scale reaction 7.2: Inert atmosphere; Large scale reaction View Scheme

<b>Multi-step reaction with 5 steps<br /> </b>1: trifluoroacetic acid / ethanol / 20 h / 50 &deg;C / Inert atmosphere<br />2: 4-methyl-morpholine / ethylene glycol dimethyl ether / 50 - 60 &deg;C / Inert atmosphere; Large scale reaction<br />3: ethylene glycol dimethyl ether / 1.75 h / 65 &deg;C / Inert atmosphere; Large scale reaction<br />4: ethanol; 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 &deg;C / Inert atmosphere<br />5: sulfuric acid / acetone / 0.83 h / 20 &deg;C / Inert atmosphere; Large scale reaction<br /> <br /> &nbsp;