1: 69 percent / tetrahydrofuran / 0.5 h / Ambient temperature; pH 4 (aq. buffer solution citric acid - sodium acetate) 2: 65 percent / aq. 50percent HOAc / 15 h / Ambient temperature View Scheme

1: 69 percent / tetrahydrofuran / 0.5 h / Ambient temperature; pH 4 (aq. buffer solution citric acid - sodium acetate) 2: 65 percent / aq. 50percent HOAc / 15 h / Ambient temperature View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 62 percent / K₂CO₃ / ethanol / 15 h / Heating<br />2: K^tBuO / tetrahydrofuran / 0.5 h / 0 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: p-TsOH / benzene / 1 h / Heating<br />2: ethanol / 16 h / Heating<br />3: t-BuOK / tetrahydrofuran / 0.5 h / 0 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 98 percent / benzene / a.) 0 deg C, 15 min, b.) r. t., overnight, c.) 19 h, reflux<br />2: 72 percent / p-TsOH / benzene / 1 h / Heating<br />3: 62 percent / K₂CO₃ / ethanol / 15 h / Heating<br />4: K^tBuO / tetrahydrofuran / 0.5 h / 0 &deg;C<br /> <br /> &nbsp;