1-苯甲酰基-4-哌啶羧酸乙酯合成路线 （共 13 条）
反应条件
triethylamine in dichloromethane T=20°C; 0.333333 h;
参考文献
Barbe, Guillaume; Charette, Andre B.
Journal of the American Chemical Society, 2008 , vol. 130, # 1 p. 18 - 19
反应条件
1: ethanolic HCl 2: K2CO3; CHCl3 View Scheme
参考文献
Prelog
Collection of Czechoslovak Chemical Communications, 1938 , vol. 10, p. 380,381
参考文献
Efange, Simon M. N.; Khare, Anil B.; Von Hohenberg, Krystyna; MacH, Robert H.; Parsons, Stanley M.; Tu, Zhude
Journal of Medicinal Chemistry, 2010 , vol. 53, # 7 p. 2825 - 2835
反应条件
sodium; ethyl acetate; benzene Erhitzen des Reaktionsprodukts mit wss. Salzsaeure; 1-<4>piperidyl-ethanone of bp 19:110 degree;
参考文献
Prelog
Collection of Czechoslovak Chemical Communications, 1938 , vol. 10, p. 380,381
反应条件
1: aq. NaOH 2: DCC 3: aq. NH3 4: 73.6 percent / LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Shao, Dong; Zou, Chunyan; Luo, Cheng; Tang, Xican; Li, Yuanchao
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 18 p. 4639 - 4642
反应条件
1: With trifluoromethylsulfonic anhydride in dichloromethane T=20°C; 0.0833333 h; 2: With diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate in dichloromethane T=20°C; 1 h; Further stages.;
参考文献
Barbe, Guillaume; Charette, Andre B.
Journal of the American Chemical Society, 2008 , vol. 130, # 1 p. 18 - 19
反应条件
1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1.17 h / -78 - 0 °C 1.2: -78 - 20 °C 2.1: sodium hydroxide; water / ethanol / 5 h / 50 °C 2.2: pH 1 View Scheme
参考文献
UBE INDUSTRIES, LTD.
Patent: US2012/149902 A1, 2012 ;
反应条件
1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1.17 h / -78 - 0 °C 1.2: -78 - 20 °C 2.1: sodium hydroxide; water / ethanol / 5 h / 50 °C 2.2: pH 1 3.1: triethylamine; diphenylphosphoranyl azide / toluene / 3 h / Reflux 3.2: 0.33 h / 20 °C 4.1: sodium hydroxide; water / ethanol / 8 h / Reflux View Scheme
参考文献
UBE INDUSTRIES, LTD.
Patent: US2012/149902 A1, 2012 ;
反应条件
diethyl ether; chloroform und Erwaermen des Reaktionsprodukts mit wss.-aethanol.Kalilauge;
参考文献
Clemo; Hoggarth
Journal of the Chemical Society, 1941 , p. 41,43
反应条件
sodium tetrahydroborate in tetrahydrofuran; methanol
Heating;
参考文献
Barbe, Guillaume; Charette, Andre B.
Journal of the American Chemical Society, 2008 , vol. 130, # 1 p. 18 - 19
