4-氧代-2-螺(哌啶-4-基)-苯并吡喃盐酸盐合成路线 （共 7 条）
反应条件
hydrogen; palladium 10 on activated carbon in isopropyl alcohol T=25°C;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; HADIDA-RUAH, Sara, Sabina; MILLER, Mark, Thomas; KALLEL, Edward, Adam; BEAR, Brian, Richard; ARUMUGAM, Vijayalaksmi; DENINNO, Michael, Paul; ZHOU, Jinglan; UY, Johnny; FRIEMAN, Bryan, A.
Patent: WO2012/112743 A1, 2012 ;
Location in patent: Page/Page column 70 ;
反应条件
1: With trifluoroacetic acid in dichloromethane 2: With sodium hydroxide in water pH=~ 14;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/65508 A1, 2008 ;
Location in patent: Page/Page column 21 ;
反应条件
1: pyrrolidine 2: aq. HCl / ethanol / Heating View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; HADIDA-RUAH, Sara, Sabina; MILLER, Mark, Thomas; KALLEL, Edward, Adam; BEAR, Brian, Richard; ARUMUGAM, Vijayalaksmi; DENINNO, Michael, Paul; ZHOU, Jinglan; UY, Johnny; FRIEMAN, Bryan, A.
Patent: WO2012/112743 A1, 2012 ;
反应条件
1: pyrrolidine / methanol / 20 h / 80 °C 2: hydrogen / palladium 10 on activated carbon / isopropyl alcohol / 25 °C View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; HADIDA-RUAH, Sara, Sabina; MILLER, Mark, Thomas; KALLEL, Edward, Adam; BEAR, Brian, Richard; ARUMUGAM, Vijayalaksmi; DENINNO, Michael, Paul; ZHOU, Jinglan; UY, Johnny; FRIEMAN, Bryan, A.
Patent: WO2012/112743 A1, 2012 ;
反应条件
hydrogenchloride in ethanol Heating;
参考文献
Yang, Lihu; Morriello, Greg; Prendergast, Kristine; Cheng, Kang; Jacks, Tom; Chan, Wanda W.-S.; Schleim, Klaus D.; Smith, Roy G.; Patchett, Arthur A.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 1 p. 107 - 112
反应条件
1: pyrrolidine 2: aq. HCl / ethanol / Heating View Scheme
参考文献
Yang, Lihu; Morriello, Greg; Prendergast, Kristine; Cheng, Kang; Jacks, Tom; Chan, Wanda W.-S.; Schleim, Klaus D.; Smith, Roy G.; Patchett, Arthur A.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 1 p. 107 - 112
反应条件
sodium tetrahydroborate
参考文献
Yang, Lihu; Morriello, Greg; Prendergast, Kristine; Cheng, Kang; Jacks, Tom; Chan, Wanda W.-S.; Schleim, Klaus D.; Smith, Roy G.; Patchett, Arthur A.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 1 p. 107 - 112
