6-氯-5-(三氟甲基)-3-吡啶羧酸甲酯合成路线 （共 11 条）
反应条件
potassium fluoride; copper(l) iodide in 1-methyl-pyrrolidin-2-one T=120°C; 3 h; Inert atmosphereLarge scale; Reagent/catalystSolventTemperatureConcentration;
参考文献
Mulder, Jason A.; Frutos, Rogelio P.; Patel, Nitinchandra D.; Qu, Bo; Sun, Xiufeng; Tampone, Thomas G.; Gao, Joe; Sarvestani, Max; Eriksson, Magnus C.; Haddad, Nizar; Shen, Sherry; Song, Jinhua J.; Senanayake, Chris H.
Organic Process Research and Development, 2013 , vol. 17, # 6 p. 940 - 945
反应条件
potassium fluoride; chloro-difluoro-acetic acid methyl ester; copper(I) bromide in N,N-dimethyl acetamide T=120°C;
参考文献
Mulder, Jason A.; Frutos, Rogelio P.; Patel, Nitinchandra D.; Qu, Bo; Sun, Xiufeng; Tampone, Thomas G.; Gao, Joe; Sarvestani, Max; Eriksson, Magnus C.; Haddad, Nizar; Shen, Sherry; Song, Jinhua J.; Senanayake, Chris H.
Organic Process Research and Development, 2013 , vol. 17, # 6 p. 940 - 945
反应条件
potassium fluoride; copper(l) iodide in N,N-dimethyl acetamide T=120°C; Reagent/catalystTemperatureConcentration;
参考文献
Mulder, Jason A.; Frutos, Rogelio P.; Patel, Nitinchandra D.; Qu, Bo; Sun, Xiufeng; Tampone, Thomas G.; Gao, Joe; Sarvestani, Max; Eriksson, Magnus C.; Haddad, Nizar; Shen, Sherry; Song, Jinhua J.; Senanayake, Chris H.
Organic Process Research and Development, 2013 , vol. 17, # 6 p. 940 - 945
反应条件
1: sulfuric acid / 22 h / |Reflux; |Large scale 2: N-iodo-succinimide / methanol / 2 h / |Reflux; |Large scale 3: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 7 h / 100 °C / |Large scale 4: copper(l) iodide; potassium fluoride / 1-methyl-pyrrolidin-2-one / 3 h / 120 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Mulder, Jason A.; Frutos, Rogelio P.; Patel, Nitinchandra D.; Qu, Bo; Sun, Xiufeng; Tampone, Thomas G.; Gao, Joe; Sarvestani, Max; Eriksson, Magnus C.; Haddad, Nizar; Shen, Sherry; Song, Jinhua J.; Senanayake, Chris H.
Organic Process Research and Development, 2013 , vol. 17, # 6 p. 940 - 945
反应条件
1: N-iodo-succinimide / methanol / 2 h / |Reflux; |Large scale 2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 7 h / 100 °C / |Large scale 3: copper(l) iodide; potassium fluoride / 1-methyl-pyrrolidin-2-one / 3 h / 120 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Mulder, Jason A.; Frutos, Rogelio P.; Patel, Nitinchandra D.; Qu, Bo; Sun, Xiufeng; Tampone, Thomas G.; Gao, Joe; Sarvestani, Max; Eriksson, Magnus C.; Haddad, Nizar; Shen, Sherry; Song, Jinhua J.; Senanayake, Chris H.
Organic Process Research and Development, 2013 , vol. 17, # 6 p. 940 - 945
反应条件
1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 7 h / 100 °C / |Large scale 2: copper(l) iodide; potassium fluoride / 1-methyl-pyrrolidin-2-one / 3 h / 120 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Mulder, Jason A.; Frutos, Rogelio P.; Patel, Nitinchandra D.; Qu, Bo; Sun, Xiufeng; Tampone, Thomas G.; Gao, Joe; Sarvestani, Max; Eriksson, Magnus C.; Haddad, Nizar; Shen, Sherry; Song, Jinhua J.; Senanayake, Chris H.
Organic Process Research and Development, 2013 , vol. 17, # 6 p. 940 - 945
反应条件
1: sulfuric acid / 22 h / |Reflux; |Large scale 2: N-iodo-succinimide / methanol / 2 h / |Reflux; |Large scale 3: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 7 h / 100 °C / |Large scale 4: chloro-difluoro-acetic acid methyl ester; potassium fluoride; copper(I) bromide / N,N-dimethyl acetamide / 120 °C View Scheme
参考文献
Mulder, Jason A.; Frutos, Rogelio P.; Patel, Nitinchandra D.; Qu, Bo; Sun, Xiufeng; Tampone, Thomas G.; Gao, Joe; Sarvestani, Max; Eriksson, Magnus C.; Haddad, Nizar; Shen, Sherry; Song, Jinhua J.; Senanayake, Chris H.
Organic Process Research and Development, 2013 , vol. 17, # 6 p. 940 - 945
反应条件
1: sulfuric acid / 22 h / |Reflux; |Large scale 2: N-iodo-succinimide / methanol / 2 h / |Reflux; |Large scale 3: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 7 h / 100 °C / |Large scale 4: copper(l) iodide; potassium fluoride / N,N-dimethyl acetamide / 120 °C View Scheme
参考文献
Mulder, Jason A.; Frutos, Rogelio P.; Patel, Nitinchandra D.; Qu, Bo; Sun, Xiufeng; Tampone, Thomas G.; Gao, Joe; Sarvestani, Max; Eriksson, Magnus C.; Haddad, Nizar; Shen, Sherry; Song, Jinhua J.; Senanayake, Chris H.
Organic Process Research and Development, 2013 , vol. 17, # 6 p. 940 - 945
反应条件
1: N-iodo-succinimide / methanol / 2 h / |Reflux; |Large scale 2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 7 h / 100 °C / |Large scale 3: chloro-difluoro-acetic acid methyl ester; potassium fluoride; copper(I) bromide / N,N-dimethyl acetamide / 120 °C View Scheme
参考文献
Mulder, Jason A.; Frutos, Rogelio P.; Patel, Nitinchandra D.; Qu, Bo; Sun, Xiufeng; Tampone, Thomas G.; Gao, Joe; Sarvestani, Max; Eriksson, Magnus C.; Haddad, Nizar; Shen, Sherry; Song, Jinhua J.; Senanayake, Chris H.
Organic Process Research and Development, 2013 , vol. 17, # 6 p. 940 - 945
反应条件
1: N-iodo-succinimide / methanol / 2 h / |Reflux; |Large scale 2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 7 h / 100 °C / |Large scale 3: copper(l) iodide; potassium fluoride / N,N-dimethyl acetamide / 120 °C View Scheme
参考文献
Mulder, Jason A.; Frutos, Rogelio P.; Patel, Nitinchandra D.; Qu, Bo; Sun, Xiufeng; Tampone, Thomas G.; Gao, Joe; Sarvestani, Max; Eriksson, Magnus C.; Haddad, Nizar; Shen, Sherry; Song, Jinhua J.; Senanayake, Chris H.
Organic Process Research and Development, 2013 , vol. 17, # 6 p. 940 - 945
