咪唑并[1,2-a]吡啶-8-甲腈合成路线 （共 5 条）
反应条件
in ethanol T=120°C; Sealed tube;
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
Location in patent: Page/Page column 90 ;
反应条件
in butan-1-ol Heating;
参考文献
Yamanaka; Miyake; Suda; Ohhara; Ogawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1556 - 1567
反应条件
sulfuric acid 48 h; Heating;
参考文献
Yamanaka; Miyake; Suda; Ohhara; Ogawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1556 - 1567
反应条件
1: 38 percent / conc. H2SO4 / 48 h / Heating 2: 57 percent / diisobutylaluminium hydride / CH2Cl2 / -60 °C View Scheme
参考文献
Yamanaka; Miyake; Suda; Ohhara; Ogawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1556 - 1567
反应条件
N-iodo-succinimide in dichloromethane
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
Location in patent: Page/Page column 90; 91 ;
