咪唑并[1,2-a]吡啶-8-甲醛合成路线 （共 9 条）
反应条件
diisobutylaluminium hydride in dichloromethane T=-60°C;
参考文献
Yamanaka; Miyake; Suda; Ohhara; Ogawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1556 - 1567
反应条件
manganese(IV) oxide in chloroform 1.5 h; Heating;
参考文献
Universite D'Auvergne Clermont 1; Universite Francois Rabelais Tours; Katholieke Universiteit Leuven
Patent: US2010/93781 A1, 2010 ;
Location in patent: Page/Page column 20; 21 ;
反应条件
diisobutylaluminium hydride in dichloromethane T=-70°C; 3 h;
参考文献
Chezal; Moreau; Delmas; Gueiffier; Blache; Grassy; Lartigue; Chavignon; Teulade
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6576 - 6584
反应条件
1: 86 percent / NaHCO3 / ethanol; H2O / 9 h / Heating 2: 21 percent / DIBALH / CH2Cl2 / 3 h / -70 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 20 p. 6576 - 6584
反应条件
1: 72 percent / butan-1-ol / Heating 2: 38 percent / conc. H2SO4 / 48 h / Heating 3: 57 percent / diisobutylaluminium hydride / CH2Cl2 / -60 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567
反应条件
1: 38 percent / conc. H2SO4 / 48 h / Heating 2: 57 percent / diisobutylaluminium hydride / CH2Cl2 / -60 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567
反应条件
1.1: sodium hydrogencarbonate / water; ethanol / 18 h / |Reflux; |Inert atmosphere 2.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C 2.2: 1 h / -78 - 20 °C / |Inert atmosphere View Scheme
反应条件
1: azido-acetic acid ethyl ester With ethanol; sodium T=-30°C; 2: 8-imidazolt;1,2-agt;pyridinecarboxaldehyde in ethanol T=-30 - 20°C;
参考文献
US2010/93781 A1, ;
Page/Page column 22 ;
反应条件
bromine in acetic acid T=20°C;
参考文献
Chezal, Jean-Michel; Paeshuyse, Jan; Gaumet, Vincent; Canitrot, Damien; Maisonial, Aurelie; Lartigue, Claire; Gueiffier, Alain; Moreau, Emmanuel; Teulade, Jean-Claude; Chavignon, Olivier; Neyts, Johan
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 2044 - 2047
