反应条件
1: benzyl 5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate With anhydrous magnesium perchlorate in acetonitrile
T=0 - 20°C; Inert atmosphere;
2: 1,2-epoxy-2-methyl-propane in acetonitrile
T=0 - 37°C; Inert atmosphere;
参考文献
Liu, Longbin; Norman, Mark H.; Lee, Matthew; Xi, Ning; Siegmund, Aaron; Boezio, Alessandro A.; Booker, Shon; Choquette, Debbie; D'Angelo, Noel D.; Germain, Julie; Yang, Kevin; Yang, Yajing; Zhang, Yihong; Bellon, Steven F.; Whittington, Douglas A.; Harmange, Jean-Christophe; Dominguez, Celia; Kim, Tae-Seong; Dussault, Isabelle
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 1868 - 1897