(2S,4S)-4-乙酰基硫代-2-羟基甲基-1-吡咯烷羧酸-2-丙酯合成路线 （共 6 条）
反应条件
in N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethyl acetate
参考文献
Shionogi Seiyaku Kabushiki Kaisha
Patent: US5317016 A1, 1994 ;
反应条件
sodium iodide in ethyl acetate; N,N-dimethyl-formamide; mineral oil
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: US5095013 A1, 1992 ;
反应条件
1: 92 percent / TEA / CH2Cl2 / 12 h / 20 °C 2: 95 percent / TEA / CH2Cl2 / 1 h / 0 °C 3: 88 percent / NaBH4; LiCl / ethanol; tetrahydrofuran / 0 °C 4: 82 percent / dimethylformamide; toluene / 3 h / 60 °C View Scheme
参考文献
Shin, Kye Jung; Koo, Ki Dong; Yoo, Kyung Ho; Kim, Dong Chan; Kim, Dong Jin; Park, Sang Woo
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 13 p. 1421 - 1425
反应条件
1: 97 percent / AcCl / 18 h / 60 °C 2: 92 percent / TEA / CH2Cl2 / 12 h / 20 °C 3: 95 percent / TEA / CH2Cl2 / 1 h / 0 °C 4: 88 percent / NaBH4; LiCl / ethanol; tetrahydrofuran / 0 °C 5: 82 percent / dimethylformamide; toluene / 3 h / 60 °C View Scheme
参考文献
Shin, Kye Jung; Koo, Ki Dong; Yoo, Kyung Ho; Kim, Dong Chan; Kim, Dong Jin; Park, Sang Woo
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 13 p. 1421 - 1425
反应条件
1: 95 percent / TEA / CH2Cl2 / 1 h / 0 °C 2: 88 percent / NaBH4; LiCl / ethanol; tetrahydrofuran / 0 °C 3: 82 percent / dimethylformamide; toluene / 3 h / 60 °C View Scheme
参考文献
Shin, Kye Jung; Koo, Ki Dong; Yoo, Kyung Ho; Kim, Dong Chan; Kim, Dong Jin; Park, Sang Woo
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 13 p. 1421 - 1425
反应条件
1: 88 percent / NaBH4; LiCl / ethanol; tetrahydrofuran / 0 °C 2: 82 percent / dimethylformamide; toluene / 3 h / 60 °C View Scheme
参考文献
Shin, Kye Jung; Koo, Ki Dong; Yoo, Kyung Ho; Kim, Dong Chan; Kim, Dong Jin; Park, Sang Woo
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 13 p. 1421 - 1425
