1.1: titanium(IV) isopropylate; n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 50 °C / Inert atmosphere 1.2: Inert atmosphere 2.1: hydrogenchloride; water / tetrahydrofuran / 15 h / 20 °C View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1.1: Cl₂Ni(1,2-bis(diphenylphosphino)ethane); 1,1-dimethylethylmagnesium chloride / tetrahydrofuran; dichloromethane / 20 &deg;C / Inert atmosphere<br />1.2: 20 &deg;C / Inert atmosphere<br />2.1: diisopropyl-carbodiimide / dichloromethane / 24 h / 20 &deg;C / Inert atmosphere<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: n-butyllithium; N,N,N',N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 0.05 h / -98 &deg;C / Inert atmosphere<br />1.2: 2 h / -98 - -60 &deg;C / Inert atmosphere<br />1.3: Inert atmosphere<br />2.1: Cl₂Ni(1,2-bis(diphenylphosphino)ethane); 1,1-dimethylethylmagnesium chloride / tetrahydrofuran; dichloromethane / 20 &deg;C / Inert atmosphere<br />2.2: 20 &deg;C / Inert atmosphere<br />3.1: diisopropyl-carbodiimide / dichloromethane / 24 h / 20 &deg;C / Inert atmosphere<br /> <br /> &nbsp;