反应条件
1.1: NaH / tetrahydrofuran / 20 °C 1.2: tetrahydrofuran / 20 °C 2.1: H2; ethanolic NH3 / Raney-Co 3.1: Et3N / tetrahydrofuran / 0 °C 4.1: 86 percent / NaOAc; Br2 / 0 °C 5.1: 94 percent / BBr3 / CH2Cl2 / 0.67 h / -20 - 20 °C 6.1: NaH / dimethylformamide / 0 °C 6.2: 96 percent / dimethylformamide / 0 °C 7.1: 80 percent / various solvent(s) / 200 - 205 °C View Scheme
参考文献
Uchikawa, Osamu; Fukatsu, Kohji; Tokunoh, Ryosuke; Kawada, Mitsuru; Matsumoto, Kiyoharu; Imai, Yumi; Hinuma, Shuji; Kato, Koki; Nishikawa, Hisao; Hirai, Keisuke; Miyamoto, Masaomi; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4222 - 4239
