1,3,8-三氮杂螺[4.5]癸烷-2,4-二酮合成路线 （共 11 条）
反应条件
hydrogen; acetic acid; palladium monocarbide in ethanol
反应条件
(NH4)2CO3 in methanol; water T=120°C; 0.133333 h; Sealed vialMicrowave irradiation;
参考文献
Rivero, Ignacio A.; Reynoso-Soto, Edgar A.; Ochoa-Teran, Adrian
Arkivoc, 2011 , vol. 2011, # 2 p. 260 - 271
反应条件
in methanol; water T=20°C; 72 h;
参考文献
Kiviranta, Paeivi H.; Leppaenen, Jukka; Rinne, Valtteri M.; Suuronen, Tiina; Kyrylenko, Olga; Kyrylenko, Sergiy; Kuusisto, Erkki; Tervo, Anu J.; Jaervinen, Tomi; Salminen, Antero; Poso, Antti; Wallen, Erik A.A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2448 - 2451
反应条件
in methanol; water 48 h; Ambient temperature;
参考文献
Wysong, Christopher L.; Yokum, T. Scott; Morales, Guillermo A.; Gundry, Rebekah L.; McLaughlin, Mark L.; Hammer, Robert P.
Journal of Organic Chemistry, 1996 , vol. 61, # 22 p. 7650 - 7651
反应条件
in ethanol; water T=80°C; P=2660 Torr; 18 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 18 p. 2519 - 2522
反应条件
1: 100 percent / DMAP, Et3N / 1,2-dimethoxy-ethane / 21 h / Ambient temperature 2: aq. NaOH / 1,2-dimethoxy-ethane / 26 h 3: H2O; 1,2-dimethoxy-ethane / 18 h / Ambient temperature; pH 9.0-9.5 View Scheme
参考文献
Wysong, Christopher L.; Yokum, T. Scott; Morales, Guillermo A.; Gundry, Rebekah L.; McLaughlin, Mark L.; Hammer, Robert P.
Journal of Organic Chemistry, 1996 , vol. 61, # 22 p. 7650 - 7651
反应条件
1: 86 percent / Et3N; DMAP / 1,2-dimethoxy-ethane / 20 °C 2: 76 percent / aq. NaOH / 1,2-dimethoxy-ethane / 48 h / 20 °C View Scheme
参考文献
Wysong, Christopher L.; Yokum, T. Scott; Morales, Guillermo A.; Gundry, Rebekah L.; McLaughlin, Mark L.; Hammer, Robert P.
Journal of Organic Chemistry, 1996 , vol. 61, # 22 p. 7650 - 7651
反应条件
triethylamine in 1,4-dioxane; water T=20°C; 2 h;
参考文献
Bleicher, Konrad H.; Wuethrich, Yves; De Boni, Maxime; Kolczewski, Sabine; Hoffmann, Torsten; Sleight, Andrew J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2519 - 2522
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in ethylene glycol dimethyl ether 21 h; Ambient temperature;
参考文献
Wysong, Christopher L.; Yokum, T. Scott; Morales, Guillermo A.; Gundry, Rebekah L.; McLaughlin, Mark L.; Hammer, Robert P.
Journal of Organic Chemistry, 1996 , vol. 61, # 22 p. 7650 - 7651
反应条件
1: 86 percent / Et3N; DMAP / 1,2-dimethoxy-ethane / 20 °C 2: 76 percent / aq. NaOH / 1,2-dimethoxy-ethane / 48 h / 20 °C 3: 78 percent / K2CO3 / H2O; dioxane / 20 °C View Scheme
参考文献
Kiviranta, Paeivi H.; Leppaenen, Jukka; Rinne, Valtteri M.; Suuronen, Tiina; Kyrylenko, Olga; Kyrylenko, Sergiy; Kuusisto, Erkki; Tervo, Anu J.; Jaervinen, Tomi; Salminen, Antero; Poso, Antti; Wallen, Erik A.A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2448 - 2451
