3-甲氧基异恶唑-5-甲酸合成路线 （共 8 条）
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide T=-5 - 20°C; 2: With sodium hydroxide in N,N-dimethyl-formamide 4 h; 3: With hydrogenchloride in N,N-dimethyl-formamide
参考文献
F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; BINGGELI, Alfred; HERTEL, Cornelia; KONKAR, Anish Ashok; KUEHNE, Holger; KUHN, Bernd; MAERKI, Hans P.; WANG, Haiyan
Patent: WO2012/89601 A1, 2012 ;
Location in patent: Page/Page column 58-59 ;
WO 2012/089601 A1
反应条件
1: With sodium hydroxide; water in N,N-dimethyl-formamide T=20°C; Inert atmosphereLarge scale reaction; 2: With hydrogenchloride in water; N,N-dimethyl-formamide 0.5 h; Inert atmosphereLarge scale reaction;
参考文献
Journal of Organic Chemistry, , vol. 74, # 12 p. 4547 - 4553
反应条件
hydrogenchloride; potassium hydroxide in methanol; water
参考文献
US5284957 A1, ;
US 5284957 A
反应条件
potassium hydroxide in water 48 h; Heating;
参考文献
Helvetica Chimica Acta, , vol. 50, p. 137 - 142
参考文献
Journal of the Chemical Society [Section] C: Organic, , p. 172 - 185
反应条件
1: dimethyl acetylenedicarboxylate With hydroxylamine 2: methyl iodide With potassium carbonate
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 14 p. 5205 - 5220
反应条件
1: Et3N / tetrahydrofuran / 1.25 h / 0 °C 2: NaBH4 / H2O / Ambient temperature 3: 80 percent / Ph3P, Br2, pyridine / CH2Cl2 / 0 °C View Scheme
参考文献
Ornstein; Arnold; Allen; Bleisch; Borromeo; Lugar; Leander; Lodge; Schoepp
Journal of Medicinal Chemistry, 1996 , vol. 39, # 11 p. 2232 - 2244
反应条件
thionyl chloride in N,N-dimethyl-formamide
0.333333 h; Heating;
参考文献
Chiarino; Fantucci; Carenzi; Della Bella; Frigeni; Sala
Farmaco, Edizione Scientifica, 1986 , vol. 41, # 6 p. 440 - 453
