magnesium; ethylene dibromide in tetrahydrofuran N2-atmosphere; treatment of mixt. of isoxazole derivative and Mg (in refluxing THF) with BrCH2CH2Br, refluxing for 2.5 h, cooling to room temp.,addn. of Sn-compd., stirring at room temp. overnight; water addn., extn. into Et2O, drying (MgSO4), filtration, concn., distn.(reduced pressure);

bis-triphenylphosphine-palladium(II) chloride in 1,4-dioxane 20 h; Heating;

1: 57 percent / Pd(PPh3)2Cl2 / dioxane / 20 h / Heating 2: 32 percent / H2 / Raney nickel W-1 / methanol / 3.5 h / 3952 Torr View Scheme