二(2-噻吩基)乙醇酸东莨菪酯合成路线 （共 12 条）
反应条件
1: With sodium t-butanolate in tetrahydrofuran; toluene T=70 - 90°C; P=375.038 Torr; 4.41667 h; Inert atmosphere; 2: With hydrogenchloride in dichloromethane; water Cooling with ice; 3: With sodium carbonate in water Reagent/catalystSolventTimeTemperaturePressureConcentration; Overall yield = 37.2 g;
参考文献
WO2013/143510 A1, ;
Page/Page column 9; 18-19 ;
反应条件
potassium tert-butylate; 1-n-butyl-3-methylimidazolium tetrafluoroborate in tetrahydrofuran T=20°C; 18 h; Molecular sieve; SolventConcentrationReagent/catalystTemperatureTime;
参考文献
WO2013/46138 A1, ;
Page/Page column 9; 10 ;
反应条件
1: With sodium t-butanolate in toluene T=70 - 90°C; P=225.023 - 300.03 Torr; 4.25 h; Inert atmosphere; 2: With hydrogenchloride in dichloromethane; water Cooling with ice; 3: With sodium carbonate in water TimeConcentration;
参考文献
WO2013/143510 A1, ;
Page/Page column 18 ;
反应条件
dihydrogen peroxide; vanadium pentoxide in N,N-dimethyl-formamide T=57°C; 4.5 h;
参考文献
Australian Journal of Chemistry, , vol. 59, # 1 p. 53 - 58
反应条件
1: With diethylamine in N,N-dimethyl-formamide; acetone T=40 - 45°C; 1.08333 h; 2: in n-heptane; N,N-dimethyl-formamide 2 h; 3: With potassium carbonate in n-heptane; N,N-dimethyl-formamide T=90 - 95°C; Inert atmosphere;
参考文献
WO2013/117886 A1, ;
Paragraph 00033 ;
反应条件
1: 6exo,7exo-epoxy-tropane-3endo-ol; scopine; hydrochloride With sodium hydride in N,N-dimethyl-formamide T=5 - 10°C; 2: 2-hydroxy-2,2-di(thiophen-2'-yl)acetic acid methyl ester With 1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide T=60°C; 5 h; Product distribution / selectivity;
参考文献
WO2009/87419 A1, ;
Page/Page column 13 ;
反应条件
in tetrahydrofuran T=-30°C; 3 h; Concentration;
参考文献
WO2013/135219 A1, ;
Page/Page column 12-13 ;
反应条件
1: 73 percent / zinc; copper / acetonitrile / 72 h / 156 °C 2: 58 percent / sodium hydroxide / 2.5 h / Heating 3: 58 percent / sodium hydride / heptane / 2.5 h / Heating 4: 80 percent / hydrogen peroxide; vanadium(V) oxide / dimethylformamide / 4.5 h / 57 °C View Scheme
参考文献
Australian Journal of Chemistry, , vol. 59, # 1 p. 53 - 58
反应条件
1: 58 percent / sodium hydroxide / 2.5 h / Heating 2: 58 percent / sodium hydride / heptane / 2.5 h / Heating 3: 80 percent / hydrogen peroxide; vanadium(V) oxide / dimethylformamide / 4.5 h / 57 °C View Scheme
参考文献
Australian Journal of Chemistry, , vol. 59, # 1 p. 53 - 58
反应条件
1: 58 percent / sodium hydride / heptane / 2.5 h / Heating 2: 80 percent / hydrogen peroxide; vanadium(V) oxide / dimethylformamide / 4.5 h / 57 °C View Scheme
参考文献
Australian Journal of Chemistry, , vol. 59, # 1 p. 53 - 58
