反应条件
1.1: hydrogen; ammonia / Raney Nickel / isopropyl alcohol; water / 22 h / 35 - 55 °C / 9000.9 Torr 1.2: pH 7 / Heating 2.1: pivalic acid potassium salt / tert-butyl methyl ether; tetrahydrofuran / 140 h / Reflux 3.1: hydrogenchloride / water; methanol / 3 h / 25 °C 3.2: 25 - 38 °C 3.3: 1 h / 58 °C View Scheme
参考文献
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.; LANGE, DE, Ben; ELSENBERG, Henricus, Leonardus, Marie
Patent: WO2012/32035 A1, 2012 ;
