(R)-(-)-N-甲基-1-苯基-2-(1-吡啶烷)乙胺合成路线 （共 10 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 6 h; Heating;
参考文献
Bhuniya, Debnath; DattaGupta, Arpita; Singh, Vinod K.
Journal of Organic Chemistry, 1996 , vol. 61, # 18 p. 6108 - 6113
反应条件
1: 1.) CuCl2, 1-hydroxybenzotriazole, DCC / 1) DMF, 0 deg C, 20 min; 2) DMF, 0 deg C --> rt, 20 h 2: 79 percent / LAH / tetrahydrofuran / 6 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 18 p. 6108 - 6113
反应条件
1: 4-methylmorpholine, isobutyl chloroformate / tetrahydrofuran / 1) -15 deg C, 1 h, 2) 23 deg C, 4 h 2: LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Tetrahedron, , vol. 49, # 5 p. 965 - 986
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Heating; Yield given. Further byproducts given. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 49, # 5 p. 965 - 986
反应条件
1: ethanol / 2 h / Heating 2: MeSO2Cl, Et3N / diethyl ether / 0.5 h / 0 °C 3: Et3N / diethyl ether; H2O / 16 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 9 p. 1483 - 1492
反应条件
1: Na2CO3, n-Bu4NI / tetrahydrofuran / 20 h / Heating 2: MeSO2Cl, Et3N / diethyl ether / 0.5 h / 0 °C 3: Et3N / diethyl ether; H2O / 16 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 9 p. 1483 - 1492
反应条件
1: MeSO2Cl, Et3N / diethyl ether / 0.5 h / 0 °C 2: Et3N / diethyl ether; H2O / 16 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 9 p. 1483 - 1492
反应条件
triethylamine in diethyl ether; water 16 h; Ambient temperature; Yield given;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 9 p. 1483 - 1492
反应条件
methanesulfonyl chloride; triethylamine 1.) EtOH, reflux; 2.) Et2O, 0 deg C, 30 min; 3.) Et2O, H2O, r.t., 16 h; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 37, # 31 p. 5619 - 5622
反应条件
methanesulfonyl chloride; triethylamine 1.) Et2O 0 deg C, 30 min, 2.) Et2O, H2O, RT, 16 h; Yield given. Multistep reaction;
参考文献
Tetrahedron Asymmetry, , vol. 8, # 15 p. 2613 - 2618
