(9CI)-8-氟吡啶并[1,2-a]苯并咪唑合成路线 （共 13 条）
反应条件
peracetic acid; iodobenzene
T=25°C; 1.5 h;
参考文献
He, Yimiao; Huang, Jinbo; Liang, Dongdong; Liu, Lanying; Zhu, Qiang
Chemical Communications, 2013 , vol. 49, # 66 p. 7352 - 7354
反应条件
PhI(OPiv)2
T=25°C; 7 h;
参考文献
Liang, Dongdong; He, Yimiao; Liu, Lanying; Zhu, Qiang
Organic Letters, 2013 , vol. 15, # 13 p. 3476 - 3479
反应条件
copper(l) iodide; 1,10-phenanthroline; caesium carbonate in anhydrous xylene
T=120°C; Ullmann type reaction; 24 h; Inert atmosphere;
参考文献
Wu, Zhiqing; Huang, Qing; Zhou, Xiangge; Yu, Lintao; Li, Zhengkai; Wu, Di
European Journal of Organic Chemistry, 2011 , # 27 p. 5242 - 5245
反应条件
1: toluene-4-sulfonic acid / tetrahydrofuran / 18 h / |Reflux; |Inert atmosphere; |Molecular sieve
2: tetrahydrofuran / -30 - 50 °C
3: PhI(OPiv)2 / 2.5 h / 25 °C
View Scheme
参考文献
Liang, Dongdong; He, Yimiao; Liu, Lanying; Zhu, Qiang
Organic Letters, 2013 , vol. 15, # 13 p. 3476 - 3479
反应条件
1.1: tert-butyl alcohol / 24 h / 25 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 5 °C
2.2: 1.5 h / 5 - 20 °C
3.1: trifluoroacetic acid / water; dichloromethane
4.1: PhI(OPiv)2 / 7 h / 25 °C
View Scheme
参考文献
Liang, Dongdong; He, Yimiao; Liu, Lanying; Zhu, Qiang
Organic Letters, 2013 , vol. 15, # 13 p. 3476 - 3479
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 5 °C
1.2: 1.5 h / 5 - 20 °C
2.1: trifluoroacetic acid / water; dichloromethane
3.1: PhI(OPiv)2 / 7 h / 25 °C
View Scheme
参考文献
Liang, Dongdong; He, Yimiao; Liu, Lanying; Zhu, Qiang
Organic Letters, 2013 , vol. 15, # 13 p. 3476 - 3479
反应条件
PhI(OPiv)2
T=25°C; 2.5 h; Overall yield = 94 percent;
参考文献
Liang, Dongdong; He, Yimiao; Liu, Lanying; Zhu, Qiang
Organic Letters, 2013 , vol. 15, # 13 p. 3476 - 3479
反应条件
1: toluene-4-sulfonic acid / tetrahydrofuran / 18 h / |Reflux; |Inert atmosphere; |Molecular sieve
2: tetrahydrofuran / -30 - 50 °C
3: PhI(OPiv)2 / 2.5 h / 25 °C
View Scheme
参考文献
Liang, Dongdong; He, Yimiao; Liu, Lanying; Zhu, Qiang
Organic Letters, 2013 , vol. 15, # 13 p. 3476 - 3479
反应条件
1: 73 percent / 5 h / 150 °C
2: 80 percent / NaOH / 2-methyl-propan-2-ol; H2O / 7 h / Irradiation
View Scheme
参考文献
Baklanov, M. V.; Frolov, A. N.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 3.2 p. 550 - 559
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 3 p. 638 - 649
反应条件
1: 73 percent / 5 h / 150 °C
2: 80 percent / NaOH / 2-methyl-propan-2-ol; H2O / 7 h / Irradiation
View Scheme
参考文献
Baklanov, M. V.; Frolov, A. N.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 3.2 p. 550 - 559
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 3 p. 638 - 649
