反应条件
1.1: hydrogen / Raney cobalt / Sec-butyl alcohol / 77 h / 50 °C / 9000.9 Torr / Inert atmosphere 2.1: 2,2,2-trimethylacetic acid / n-heptane; tetrahydrofuran / 48 h / Reflux; Azeotropic distillation of water 3.1: hydrogenchloride; water / methanol / 3.17 h / 25 - 30 °C 3.2: 25 - 38 °C 3.3: 2 h / 48 - 58 °C View Scheme
参考文献
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.; De Lange, Ben; Elsenberg, Henricus Leonardus Marie; Vaessen, Henricus Wilhelmus Leonardus Marie
Patent: US2013/178636 A1, 2013 ;
