1-溴-2-氟-4-碘苯合成路线 （共 10 条）
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite 1.) H2O, 0 deg C, 30 min, 2.) H2O, reflux, 15 min; Yield givenMultistep reaction;
参考文献
Journal of the Chemical Society. Perkin Transactions 2, , # 3 p. 481 - 491
反应条件
hydrogen bromide; acetic acid; sodium nitrite in sulfuric acid; water
反应条件
1: 77 percent / I2, NaHCO3 / H2O / 2 h / 60 - 80 °C 2: 1.) NaNO2, HBr, 2.) CuBr, HBr / 1.) H2O, 0 deg C, 30 min, 2.) H2O, reflux, 15 min View Scheme
参考文献
Journal of the Chemical Society. Perkin Transactions 2, , # 3 p. 481 - 491
反应条件
1: 70 percent / acetic acid / 0.33 h / Heating 2: 100 percent / NBS / CH2Cl2 / a) reflux, 5 h, b) room temp., 16 h 3: 99 percent / 36percent HCl / ethanol / 2 h / Heating 4: 1) 36percent HCl, NaNO2, 2) KI / 1) H2O, 0 deg C, 20 min, 2) H2O, cyclohexane, room temp., 16 h View Scheme
参考文献
Molecular Crystals and Liquid Crystals (1969-1991), , vol. 204, p. 43 - 64
反应条件
1: 100 percent / NBS / CH2Cl2 / a) reflux, 5 h, b) room temp., 16 h 2: 99 percent / 36percent HCl / ethanol / 2 h / Heating 3: 1) 36percent HCl, NaNO2, 2) KI / 1) H2O, 0 deg C, 20 min, 2) H2O, cyclohexane, room temp., 16 h View Scheme
参考文献
Molecular Crystals and Liquid Crystals (1969-1991), , vol. 204, p. 43 - 64
反应条件
1: 99 percent / 36percent HCl / ethanol / 2 h / Heating 2: 1) 36percent HCl, NaNO2, 2) KI / 1) H2O, 0 deg C, 20 min, 2) H2O, cyclohexane, room temp., 16 h View Scheme
参考文献
Molecular Crystals and Liquid Crystals (1969-1991), , vol. 204, p. 43 - 64
反应条件
hydrogenchloride; potassium iodide; sodium nitrite 1) H2O, 0 deg C, 20 min, 2) H2O, cyclohexane, room temp., 16 h; Yield given. Multistep reaction;
参考文献
Molecular Crystals and Liquid Crystals (1969-1991), , vol. 204, p. 43 - 64
参考文献
Seiko Epson Corporation
Patent: US5437815 A1, 1995 ;
反应条件
1.1: LDA / tetrahydrofuran / 1 h / -78 °C 1.2: tetrahydrofuran / -78 - 20 °C 2.1: SOCl2 / 3 h / 80 °C 3.1: aq. NH3 / tetrahydrofuran / 20 °C 4.1: SOCl2 / dimethylformamide / 16 h / 115 °C View Scheme
参考文献
Hird, Michael; Lewis, Robert A.; Toyne, Kenneth J.; West, Jonathan J.; Wilson, Michael K.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 20 p. 3479 - 3484
反应条件
[2,2']bipyridinyl; niobium bromide; zinc in N,N-dimethyl-formamide
T=80°C; 0.166667 h;
参考文献
SMITH KLINE BEECHAM CORPORATION a corporation
Patent: US2010/29650 A1, 2010 ;
Location in patent: Page/Page column 77 ;
