hydrogenchloride in tetrahydrofuran

1: With lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: With boric acid trimethyl ester in tetrahydrofuran; hexane T=-78 - 20°C; 1 h; 3: With sodium hydroxide in tetrahydrofuran; hexane Further stages.;

hydrogenchloride; n-butyllithium; diisopropylamine in tetrahydrofuran

n-BuLi; diisopropylamine in diethyl ether; hexane under N2 atm. to soln. DIPA in Et2O at -78°C n-BuLi in hexane wasadded over 20 min and stirred for 1 h at -78°C, 2,6-difluoropyri dine was added and stirred for 1 h, B(OMe)3 was added at -78°C, warmed to room temp, stirred for 1 h; aq. NaOH was added, stirred for 10 min, HCl was added, react. mixt. was extd. with EtOAc; elem. anal.;