1-(4-溴苯基)-3-氧代环丁烷羧酸甲酯合成路线 （共 1 条）
反应条件
1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 20 °C / |Cooling with ice 1.2: 3 h / 20 - 26 °C 1.3: 20 °C / |Heating 2.1: sulfuric acid / 20 °C / |Reflux 3.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / chloroform / 24 h / 20 °C / |Cooling with ice View Scheme
参考文献
TAIHO PHARMACEUTICAL CO., LTD.; Nakamura, Masayuki; Niiyama, Kenji; Kamijo, Kaori; Ohkubo, Mitsuru; Shimomura, Toshiyasu
Patent: US2014/5185 A1, 2014 ;
