N-乙基-3,4-二氟苯胺合成路线 （共 5 条）
反应条件
N-ethyl-N,N-diisopropylamine in toluene T=90°C; 24 h;
参考文献
Piras, Sandra; Carta, Antonio; Briguglio, Irene; Corona, Paola; Paglietti, Giuseppe; Luciani, Rosaria; Costi, Maria Paola; Ferrari, Stefania
European Journal of Medicinal Chemistry, 2014 , vol. 75, p. 169 - 183
反应条件
hydrogenchloride in water 2 h; Heating;
参考文献
Jordis, Ulrich; Sauter, Fritz; Burkart, Michael; Henning, Hans-Georg; Gelbin, Anke
Journal fuer Praktische Chemie (Leipzig), 1991 , vol. 333, # 2 p. 267 - 279
反应条件
1: 72.5 percent / conc. H2SO4 / 1.5 h / 175 °C 2: 77 percent / conc. HCl / H2O / 2 h / Heating View Scheme
参考文献
Jordis, Ulrich; Sauter, Fritz; Burkart, Michael; Henning, Hans-Georg; Gelbin, Anke
Journal fuer Praktische Chemie (Leipzig), 1991 , vol. 333, # 2 p. 267 - 279
反应条件
1: 62 percent / 0.5 h / 90 - 100 °C 2: 71 percent / PPA / toluene / 0.58 h / 100 °C 3: dimethylsulfoxide / 40 °C / or over the mixed anhydrides with BF3 or BBr3 (facilitate the aromatic substitution) View Scheme
参考文献
Jordis, Ulrich; Sauter, Fritz; Burkart, Michael; Henning, Hans-Georg; Gelbin, Anke
Journal fuer Praktische Chemie (Leipzig), 1991 , vol. 333, # 2 p. 267 - 279
反应条件
1: 62 percent / 0.5 h / 90 - 100 °C
2: 71 percent / PPA / toluene / 0.58 h / 100 °C
View Scheme
参考文献
Jordis, Ulrich; Sauter, Fritz; Burkart, Michael; Henning, Hans-Georg; Gelbin, Anke
Journal fuer Praktische Chemie (Leipzig), 1991 , vol. 333, # 2 p. 267 - 279
