1: With sodium hypochlorite; sodium chlorite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical in water; acetonitrile T=20 - 35°C; 22 h; Aqueous phosphate buffer; 2: With sodium hydroxide in water; acetonitrile pH=8.0; 3: With hydrogenchloride in water pH=3.4; Product distribution / selectivity;

1: 95 percent / sodium ethoxide / ethanol / 0.5 h / 20 °C 2: 72 percent / KOH / H2O / 15 h / 20 °C 3: 99 percent / 3 h / 130 °C View Scheme

1: Et2NH / 0.5 h / Heating 2: 43.16 g / toluene-p-sulfonic acid / methanol / Heating 3: 95 percent / sodium ethoxide / ethanol / 0.5 h / 20 °C 4: 72 percent / KOH / H2O / 15 h / 20 °C 5: 99 percent / 3 h / 130 °C View Scheme

1: 43.16 g / toluene-p-sulfonic acid / methanol / Heating 2: 95 percent / sodium ethoxide / ethanol / 0.5 h / 20 °C 3: 72 percent / KOH / H2O / 15 h / 20 °C 4: 99 percent / 3 h / 130 °C View Scheme

1: 72 percent / KOH / H2O / 15 h / 20 °C 2: 99 percent / 3 h / 130 °C View Scheme