(3S,4a,8aS)-2-[(2R,3S)-3-氨基-2-羟基-4-苯基丁基]-N-叔丁基十氢异喹啉-3-甲酰胺合成路线 （共 64 条）
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran; methanol; acetic acid P=760 Torr;
参考文献
Parkes, Kevin E. B.; Bushnell, David J.; Crackett, Peter H.; Dunsdon, Stephen J.; Freeman, Andrew C.; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3656 - 3664
反应条件
1: 60.3 percent / propan-2-ol / 5 h / Heating 2: m-cresol; thioanisole; 1,2-ethanedithiol / TFA; TMSBr / 2 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 9 p. 1764 - 1768
反应条件
hydrogen; palladium on activated charcoal in ethanol 24 h;
参考文献
Parkes, Kevin E. B.; Bushnell, David J.; Crackett, Peter H.; Dunsdon, Stephen J.; Freeman, Andrew C.; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3656 - 3664
反应条件
1: SOCl2 / CCl4 / 0.5 h / Heating 2: RuCl3*3H2O, NaIO4 / acetonitrile; H2O / 1 h / Ambient temperature 3: 2.) 10percent H2SO4 / 1.) THF, r.t., 2.) 70percent aq. MeOH, reflux, 4 h 4: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h / 2585.7 Torr / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 13 p. 3656 - 3664
反应条件
sodium hydroxide in ethanol T=80°C;
参考文献
Goehring, Wolfgang; Gokhale, Surendra; Hilpert, Hans; Roessler, Felix; Schlageter, Markus; Vogt, Peter
Chimia, 1996 , vol. 50, # 11 p. 532 - 537
反应条件
1: 84 percent / propan-2-ol / 80 °C 2: H2, AcOH / 10percent Pd/C / methanol; tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 8 p. 1177 - 1188
反应条件
trifluoroacetic acid 1 h; Ambient temperature;
参考文献
Parkes, Kevin E. B.; Bushnell, David J.; Crackett, Peter H.; Dunsdon, Stephen J.; Freeman, Andrew C.; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3656 - 3664
反应条件
1: 60.3 percent / propan-2-ol / 5 h / Heating 2: m-cresol; thioanisole; 1,2-ethanedithiol / TFA; TMSBr / 2 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 9 p. 1764 - 1768
反应条件
1: 80 percent / Et3N / methanol 2: TFA / CH2Cl2 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 121, # 6 p. 1145 - 1155
反应条件
1: 70 percent / aq. HCl 2: COCl2 4: 85 percent / H2 / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr 5: dimethylformamide / 120 °C 6: 1.) MeNH2, 2.) HCl View Scheme
参考文献
Chimia, , vol. 50, # 11 p. 532 - 537
