(3S,4a,8aS)-2-[(2R,3S)-3-氨基-2-羟基-4-苯基丁基]-N-叔丁基十氢异喹啉-3-甲酰胺合成路线 （共 64 条）
反应条件
1: 92 percent / 1 M aq. NaOH / ethanol / 18 h / Ambient temperature 2: (COCl)2, DMF / toluene / 1 h 3: CBrCl3, 2-mercaptopyridine N-oxide sodium salt, 4-(dimethylamino)pyridine / 1 h / 80 °C / Irradiation 4: aq. AcOH, conc. HCl / 3 h / Ambient temperature 5: 92 percent / KOH / methanol / 3 h / Ambient temperature 6: 86 percent / propan-2-ol / 6 h / 80 °C 7: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 13 p. 3656 - 3664
反应条件
1: 89 percent / TsOH*H2O / 5 h / 60 °C 2: 92 percent / 1 M aq. NaOH / ethanol / 18 h / Ambient temperature 3: (COCl)2, DMF / toluene / 1 h 4: CBrCl3, 2-mercaptopyridine N-oxide sodium salt, 4-(dimethylamino)pyridine / 1 h / 80 °C / Irradiation 5: aq. AcOH, conc. HCl / 3 h / Ambient temperature 6: 92 percent / KOH / methanol / 3 h / Ambient temperature 7: 86 percent / propan-2-ol / 6 h / 80 °C 8: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 13 p. 3656 - 3664
反应条件
3: H2 / Pd/C 4: 85 percent / H2 / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr 5: dimethylformamide / 120 °C 6: 1.) MeNH2, 2.) HCl View Scheme
参考文献
Chimia, , vol. 50, # 11 p. 532 - 537
反应条件
2: 85 percent / H2 / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr 3: dimethylformamide / 120 °C 4: 1.) MeNH2, 2.) HCl View Scheme
参考文献
Chimia, , vol. 50, # 11 p. 532 - 537
反应条件
1: 85 percent / H2 / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr 2: dimethylformamide / 120 °C 3: 1.) MeNH2, 2.) HCl View Scheme
参考文献
Chimia, , vol. 50, # 11 p. 532 - 537
反应条件
1: H2 / Pd/C 2: 85 percent / H2 / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr 3: dimethylformamide / 120 °C 4: 1.) MeNH2, 2.) HCl View Scheme
参考文献
Chimia, , vol. 50, # 11 p. 532 - 537
反应条件
1: 2.) H3O(+) / 1.) 90 deg C 3: NaBH4 5: p-TsOH, EtOH 6: t-BuOK 7: dimethylformamide / 120 °C 8: 1.) MeNH2, 2.) HCl View Scheme
参考文献
Chimia, , vol. 50, # 11 p. 532 - 537
反应条件
1: dimethylformamide / 120 °C 2: 1.) MeNH2, 2.) HCl View Scheme
参考文献
Chimia, , vol. 50, # 11 p. 532 - 537
反应条件
2: NaBH4 4: p-TsOH, EtOH 5: t-BuOK 6: dimethylformamide / 120 °C 7: 1.) MeNH2, 2.) HCl View Scheme
参考文献
Chimia, , vol. 50, # 11 p. 532 - 537
反应条件
1: 1.) carbonyldiimidazole 2: NaBH4 / ethanol / 1 h / -15 - -10 °C 3: 80 percent / TsOH*H2O / 1.) r.t., 24 h, 2.) 50 deg C, 7 h 4: 100 percent / 1 M aq. NaOH / ethanol / 18 h / Ambient temperature 5: (COCl)2, DMF / toluene / 1 h 6: CBrCl3, 2-mercaptopyridine N-oxide sodium salt, 4-(dimethylamino)pyridine / 1 h / 80 °C / Irradiation 7: aq. AcOH, conc. HCl / 3 h / Ambient temperature 8: 100 percent / KOH / methanol / 3 h / Ambient temperature 9: 84 percent / propan-2-ol / 1.) 70 deg C, 9 h, 2.) r.t., 16 h 10: 86 percent / trifluoroacetic acid / 1 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 13 p. 3656 - 3664
